Publications

Xu S, Wang N, Zuccaro MV, Gerhardt J, Iyyappan R, Scatolin GNascimento, Jiang Z, Baslan T, Koren A, Egli D.  2024.  DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility.. Nat Commun. 15(1):5247.

Edwards MM, Wang N, Sagi I, Kinreich S, Benvenisty N, Gerhardt J, Egli D, Koren A.  2024.  Parent-of-origin-specific DNA replication timing is confined to large imprinted regions.. Cell Rep. 43(9):114700.

Barreto-Galvez A, Niljikar M, Gagliardi J, Zhang R, Kumar V, Juruwala A, Pradeep A, Shaikh A, Tiwari P, Sharma K et al..  2023.  Acetyl transferase EP300 deficiency leads to chronic replication stress mediated by defective fork protection at stalled replication forks.. bioRxiv.

Gerhardt J.  2023.  The discovery of simple repeats that cause complex disorders.. Nat Rev Mol Cell Biol.

Madireddy A, Gerhardt J.  2023.  Visualizing DNA replication by single-molecule analysis of replicated DNA.. STAR Protoc. 4(4):102721.

Deshpande M, Paniza T, Jalloul N, Nanjangud G, Twarowski J, Koren A, Zaninovic N, Zhan Q, Chadalavada K, Malkova A et al..  2022.  Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells.. Mol Cell. 82(20):3781-3793.e7.

Jasra S, Giricz O, Zeig-Owens R, Pradhan K, Goldfarb DG, Barreto-Galvez A, Silver AJ, Chen J, Sahu S, Gordon-Mitchell S et al..  2022.  High burden of clonal hematopoiesis in first responders exposed to the World Trade Center disaster.. Nat Med. 28(3):468-471.

Ding Q, Edwards MM, Wang N, Zhu X, Bracci AN, Hulke ML, Hu Y, Tong Y, Hsiao J, Charvet CJ et al..  2021.  The genetic architecture of DNA replication timing in human pluripotent stem cells.. Nat Commun. 12(1):6746.

Fan Y, Köberlin MS, Ratnayeke N, Liu C, Deshpande M, Gerhardt J, Meyer T.  2021.  LRR1-mediated replisome disassembly promotes DNA replication by recycling replisome components.. J Cell Biol. 220(8)

Deshpande M, Romanski PA, Rosenwaks Z, Gerhardt J.  2020.  Gynecological Cancers Caused by Deficient Mismatch Repair and Microsatellite Instability.. Cancers (Basel). 12(11)

Paniza T, Deshpande M, Wang N, O'Neil R, Zuccaro MV, Smith MElizabeth, Madireddy A, James D, Ecker J, Rosenwaks Z et al..  2020.  Pluripotent stem cells with low differentiation potential contain incompletely reprogrammed DNA replication.. J Cell Biol. 219(9)

Deshpande M, Gerhardt J.  2018.  Break-induced replication sparks CGG-repeat instability.. Nat Struct Mol Biol. 25(8):643-644.

Lekovich J, Man L, Xu K, Canon C, Lilienthal D, Stewart JD, Pereira N, Rosenwaks Z, Gerhardt J.  2018.  CGG repeat length and AGG interruptions as indicators of fragile X-associated diminished ovarian reserve.. Genet Med. 20(9):957-964.

Guler GD, Rosenwaks Z, Gerhardt J.  2018.  Human DNA Helicase B as a Candidate for Unwinding Secondary CGG Repeat Structures at the Gene.. Front Mol Neurosci. 11:138.

Gerhardt J.  2017.  Epigenetic modifications in human fragile X pluripotent stem cells; Implications in fragile X syndrome modeling.. Brain Res. 1656:55-62.

Man L, Lekovich J, Rosenwaks Z, Gerhardt J.  2017.  Fragile X-Associated Diminished Ovarian Reserve and Primary Ovarian Insufficiency from Molecular Mechanisms to Clinical Manifestations.. Front Mol Neurosci. 10:290.

Madireddy A, Gerhardt J.  2017.  Replication Through Repetitive DNA Elements and Their Role in Human Diseases.. Adv Exp Med Biol. 1042:549-581.

Madireddy A, Kosiyatrakul ST, Boisvert RA, Herrera-Moyano E, García-Rubio ML, Gerhardt J, Vuono EA, Owen N, Yan Z, Olson S et al..  2016.  FANCD2 Facilitates Replication through Common Fragile Sites.. Mol Cell. 64(2):388-404.

Reichman D, Man L, Park L, Lis R, Gerhardt J, Rosenwaks Z, James D.  2016.  Notch hyper-activation drives trans-differentiation of hESC-derived endothelium.. Stem Cell Res. 17(2):391-400.

Gerhardt J, Bhalla AD, Butler JSergeskett, Puckett JW, Dervan PB, Rosenwaks Z, Napierala M.  2016.  Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich's Ataxia Cells.. Cell Rep. 16(5):1218-1227.

Gerhardt J, Guler GD, Fanning E.  2015.  Human DNA helicase B interacts with the replication initiation protein Cdc45 and facilitates Cdc45 binding onto chromatin.. Exp Cell Res. 334(2):283-93.

Gerhardt J, Zaninovic N, Zhan Q, Madireddy A, Nolin SL, Ersalesi N, Yan Z, Rosenwaks Z, Schildkraut CL.  2014.  Cis-acting DNA sequence at a replication origin promotes repeat expansion to fragile X full mutation.. J Cell Biol. 206(5):599-607.

Gerhardt J, Tomishima MJ, Zaninovic N, Colak D, Yan Z, Zhan Q, Rosenwaks Z, Jaffrey SR, Schildkraut CL.  2014.  The DNA replication program is altered at the FMR1 locus in fragile X embryonic stem cells.. Mol Cell. 53(1):19-31.

Colak D, Zaninovic N, Cohen MS, Rosenwaks Z, Yang W-Y, Gerhardt J, Disney MD, Jaffrey SR.  2014.  Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome.. Science. 343(6174):1002-5.

Zhao X, Madden-Fuentes RJ, Lou BX, Pipas JM, Gerhardt J, Rigell CJ, Fanning E.  2008.  Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells.. J Virol. 82(11):5316-28.