Publications

Deshpande M, Paniza T, Brown R, Heslin K, Patel N, Madireddy A, Rosenwaks Z, Gerhardt J.  2026.  Endogenous and environmental factors that induce DNA replication defects and genomic instability in ER-negative heterozygous BRCA1 cells.. Sci Rep. 16(1)

McCarter K, Deshpande M, Romanski P, Stratopoulou CAnna, Zaninovic N, Tareen M, Al-Mousawi R, James D, Madireddy A, Rosenwaks Z et al..  2025.  Dysregulation of the actin cytoskeleton and FMRP causes polar body protrusion defects in human fragile X premutation and aged oocytes.. bioRxiv.

Barreto-Galvez A, Niljikar M, Gagliardi JElizabeth, Guzman CPlasencia, Zhang R, Kumar V, Juwarwala A, Pradeep A, Saxena A, Montagna C et al..  2025.  EP300 deficiency leads to chronic replication stress mediated by defective replication fork protection.. Nat Commun. 17(1):475.

Deshpande M, Gerhardt J.  2025.  Protocol to Establish Estrogen Receptor-Negative Heterozygous BRCA1 Organoids.. Methods Protoc. 8(6)

Ummarino S, Poluben L, Ebralidze AK, Autiero I, Zhang Y, Paniza T, Deshpande M, Rinaldi L, Lee JD, Bassal MA et al..  2025.  RNAs anchoring replication complex control initiation and firing of DNA replication.. Res Sq.

Xu S, Wang N, Zuccaro MV, Gerhardt J, Iyyappan R, Scatolin GNascimento, Jiang Z, Baslan T, Koren A, Egli D.  2024.  DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility.. Nat Commun. 15(1):5247.

Edwards MM, Wang N, Sagi I, Kinreich S, Benvenisty N, Gerhardt J, Egli D, Koren A.  2024.  Parent-of-origin-specific DNA replication timing is confined to large imprinted regions.. Cell Rep. 43(9):114700.

Barreto-Galvez A, Niljikar M, Gagliardi J, Zhang R, Kumar V, Juruwala A, Pradeep A, Shaikh A, Tiwari P, Sharma K et al..  2023.  Acetyl transferase EP300 deficiency leads to chronic replication stress mediated by defective fork protection at stalled replication forks.. bioRxiv.

Gerhardt J.  2023.  The discovery of simple repeats that cause complex disorders.. Nat Rev Mol Cell Biol.

Madireddy A, Gerhardt J.  2023.  Visualizing DNA replication by single-molecule analysis of replicated DNA.. STAR Protoc. 4(4):102721.

Deshpande M, Paniza T, Jalloul N, Nanjangud G, Twarowski J, Koren A, Zaninovic N, Zhan Q, Chadalavada K, Malkova A et al..  2022.  Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells.. Mol Cell. 82(20):3781-3793.e7.

Jasra S, Giricz O, Zeig-Owens R, Pradhan K, Goldfarb DG, Barreto-Galvez A, Silver AJ, Chen J, Sahu S, Gordon-Mitchell S et al..  2022.  High burden of clonal hematopoiesis in first responders exposed to the World Trade Center disaster.. Nat Med. 28(3):468-471.

Ding Q, Edwards MM, Wang N, Zhu X, Bracci AN, Hulke ML, Hu Y, Tong Y, Hsiao J, Charvet CJ et al..  2021.  The genetic architecture of DNA replication timing in human pluripotent stem cells.. Nat Commun. 12(1):6746.

Fan Y, Köberlin MS, Ratnayeke N, Liu C, Deshpande M, Gerhardt J, Meyer T.  2021.  LRR1-mediated replisome disassembly promotes DNA replication by recycling replisome components.. J Cell Biol. 220(8)

Deshpande M, Romanski PA, Rosenwaks Z, Gerhardt J.  2020.  Gynecological Cancers Caused by Deficient Mismatch Repair and Microsatellite Instability.. Cancers (Basel). 12(11)

Paniza T, Deshpande M, Wang N, O'Neil R, Zuccaro MV, Smith MElizabeth, Madireddy A, James D, Ecker J, Rosenwaks Z et al..  2020.  Pluripotent stem cells with low differentiation potential contain incompletely reprogrammed DNA replication.. J Cell Biol. 219(9)

Deshpande M, Gerhardt J.  2018.  Break-induced replication sparks CGG-repeat instability.. Nat Struct Mol Biol. 25(8):643-644.

Lekovich J, Man L, Xu K, Canon C, Lilienthal D, Stewart JD, Pereira N, Rosenwaks Z, Gerhardt J.  2018.  CGG repeat length and AGG interruptions as indicators of fragile X-associated diminished ovarian reserve.. Genet Med. 20(9):957-964.

Guler GD, Rosenwaks Z, Gerhardt J.  2018.  Human DNA Helicase B as a Candidate for Unwinding Secondary CGG Repeat Structures at the Gene.. Front Mol Neurosci. 11:138.

Gerhardt J.  2017.  Epigenetic modifications in human fragile X pluripotent stem cells; Implications in fragile X syndrome modeling.. Brain Res. 1656:55-62.

Man L, Lekovich J, Rosenwaks Z, Gerhardt J.  2017.  Fragile X-Associated Diminished Ovarian Reserve and Primary Ovarian Insufficiency from Molecular Mechanisms to Clinical Manifestations.. Front Mol Neurosci. 10:290.

Madireddy A, Gerhardt J.  2017.  Replication Through Repetitive DNA Elements and Their Role in Human Diseases.. Adv Exp Med Biol. 1042:549-581.

Madireddy A, Kosiyatrakul ST, Boisvert RA, Herrera-Moyano E, García-Rubio ML, Gerhardt J, Vuono EA, Owen N, Yan Z, Olson S et al..  2016.  FANCD2 Facilitates Replication through Common Fragile Sites.. Mol Cell. 64(2):388-404.

Reichman D, Man L, Park L, Lis R, Gerhardt J, Rosenwaks Z, James D.  2016.  Notch hyper-activation drives trans-differentiation of hESC-derived endothelium.. Stem Cell Res. 17(2):391-400.

Gerhardt J, Bhalla AD, Butler JSergeskett, Puckett JW, Dervan PB, Rosenwaks Z, Napierala M.  2016.  Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich's Ataxia Cells.. Cell Rep. 16(5):1218-1227.